- Title
- The supramolecular self-assembly of aminoglycoside antibiotics and their applications
- Creator
- Jadhav, Ratan W.; Kobaisi, Mohammad Al; Jones, Lathe A.; Vinu, Ajayan; Bhosale, Sheshanath V.
- Relation
- ChemistryOpen Vol. 8, Issue 9, p. 1154-1166
- Publisher Link
- http://dx.doi.org/10.1002/open.201900193
- Publisher
- Wiley - V C H Verlag GmbH
- Resource Type
- journal article
- Date
- 2019
- Description
- Aminoglycosides, a class of antibiotics that includes gentamicin, kanamycin, neomycin, streptomycin, tobramycin and apramycin, are derived from various streptomyces species. Despite the significant increase in the antibacterial resistant pathogens, aminoglycosides remain an important class of antimicrobial drugs due to their unique chemical structure which offers a broad spectrum of activity. The modification of antibiotics and their subsequent use in supramolecular chemistry is rarely reported. Given the importance of aminoglycosides, here we give a brief overview on the modification of 4,5- and 4,6-disubstituted deoxystreptamine classes of aminoglycosides through supramolecular chemistry and their potential for real world applications. We also make the case that the work in this area is gaining momentum, and there are significant opportunities to meet the challenges of modern antibiotics through the modification of aminoglycosides by harnessing the advantages of supramolecular chemistry.
- Subject
- supramolecular self-assemblies; aminoglycosides; antibiotics; DNA; superstructures
- Identifier
- http://hdl.handle.net/1959.13/1408501
- Identifier
- uon:35848
- Identifier
- ISSN:2191-1363
- Rights
- © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
- Language
- eng
- Full Text
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